Endocrine Abstracts

Tuberous sclerosis complex is characterised by non-malignant tumours in the skin, brain, kidneys, heart, eyes, lung, but sometimes angiomyolipomas may develop in the adrenals, ovaries, thyroid, and rarely neuroendocrine tumours in the pancreas, pituitary gland, parathyroids. The case of a 46-years-old female patient suffering of tuberous sclerosis and endocrine disturbances is presented. She is known with temporal lobe epilepsy since early childhood, and anxious depressive dis...

Insulin resistance has a pivotal role in the pathogenesis of polycystic ovarian syndrome (PCOS), thus insulin sensitizer therapy is beneficial. Purpose. Our purpose was to study the effectiveness of metformin in PCOS women, including those without insulin resistance. Matherials and methods. This study was conducted on 24 pacients (12 obese or overweight and 12 lean women), aged 21–31 years, diagnosed and treated with PCOS at the Clinical Department of Endocrinology Targu-...

Regular red blood cell transfusions for thalassemia major leads to iron overload in endocrine glands, inducing deficient function of the pituitary, thyroid, parathyroid etc. In thalassemia intermedia these endocrine disturbances may appear due to increased intestinal iron absorption and occasional transfusions, but are less frequent and milder. We have no data about their presence in thalassemia minor.We present the case of a young woman known with mild ...

Objective: To study thyroid microcarcinomas in surgical samples obtained by thyroidectomy.Material and methods: We studied 311 patients thyroidectomized for different thyroid diseases in 2007, histology being made in the Institute of Pathology Tg.Mures.Results: Surgery was made for uni- and multinodular goiter in 278, for Graves-disease in 28, and for other forms of hyperthyro-i-dism in 5 cases. Thyroid cancer was diagnosed in 65 c...

In our previous studies, we determined the incidence of thyroid dysfunctions in pregnant women in endocrinological out-patient departments, comparing the frequency and nature of gestational complications in hypothyroid pregnant women versus pregnants without thyroid disturbances. In the present study, we proposed to appreciate thyroid dysfunctions in a clinical section of pregnant women with gestational pathology. We investigated 75 pregnant women hospitalized in the Clinic of...

The perchlorates block the enzyme NIS, inhibiting iodine accumulation in the thyroid and favour the elimination of intrathyroidal iodine unused for hormone synthesis. Their therapeutical utilisation actually is limited due to the toxicity. In the literature there are different opinions regarding the adverse effects (nephrotic syndrome, irreversible aplastic anemia etc.), but several authors sustain that these appear only after high doses, and after the development of therapeut...

Introduction: Iodine may aggravate maternal autoimmune thyroid diseases during and after pregnancy, but selenium could defend against it’s harmful effect. Objective: to study the course and complications of Hashimoto’s thyroiditis in pregnant and lactating women receiving iodine and selenium therapy. Material and method. Serum TSH, free-T4 and anti-thyroid peroxidase-antibody were measured in 30 women with chronic autoimmune thyroiditis in every gestational trimester...

Introduction: In iodine deficient regions maternal iodine supply is indispensable for the normal development of the fetus, but it might aggravate autoimmune thyroid diseases in the mother during pregnancy and postpartum. Selenium might be beneficent in these thyroid diseases by defending against the harmful effect of iodine on maternal thyroiditis.Objective: To study the course of Hashimoto’s thyroiditis in pregnant women, under combined therapy wit...

Introduction: The urinary iodine excretion (UIE) from fasting morning urine sample is a good epidemiologic indicator for iodine state, used in populational groups (schoolchildren, pregnant women) at risk to develop iodine deficiency disorders. It is not adequate to evaluate individual iodine intake. In pregnant women, especially with chronic autoimmune thyroiditis, it is important to estimate iodine state.Objectives: To evaluate the individual iodine sta...

Introduction: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder, most commonly caused by CYP21A2 mutations, and characterized by disturbed cortisol and androgen synthesis. Clinical manifestations of classical 21-hydroxylase deficiency are virilisation and salt-waisting syndrome in both sexes. Adrenal tumors may appear in untreated CAH patients, but very rarely following adequate long-term therapy.Case report: The 17-years-old male p...